歐洲驚曝“捐精災難”，近200名新生兒極大概率患癌

據外媒報道，歐洲一名匿名捐精者促成至少197名兒童的誕生，然而后來查出，捐精者部分精子有致癌基因。近日調查顯示，部分孩子已確診癌癥且不幸死亡。

Sperm from a donor who unknowingly carried a cancer-causing gene has been used to conceive nearly 200 babies across Europe, an investigation by 14 European public service broadcasters, including CBS News' partner network BBC News, has revealed.

Some children conceived using the sperm have already died from cancer, and the vast majority of those who inherited the gene will develop cancer in their lifetimes, geneticists said.

conceive /k?n?si?v/ 受孕

該男子當時通過所有健康檢查，本人及家族無疾病癥狀，但如今發現其約20%精子攜帶TP53基因突變，會使由這些受影響的精子受孕的孩子罹患“李佛美尼綜合征”，患癌概率高達90%。兒童時期易發病，長大后可能患乳腺癌，需定期檢查，女性或需預防性乳房切除。

The man carrying the gene passed screening checks before he became a donor at the European Sperm Bank when he was a student in 2005.

screening /?skri?n??/ 篩查

The cancer-causing mutation occurred in the donor's TP53 gene — which prevents cells in the body from turning cancerous — before his birth, according to the investigation. It causes Li Fraumeni syndrome, which gives affected people a 90 percent chance of developing cancers, particularly during childhood, as well as breast cancer in later life.

Up to 20 percent of the donor's sperm contained the mutated TP53 gene. Any children conceived with affected sperm will have the dangerous mutation in every cell of their body.

今年5月媒體報道，當時確認的67名兒童中，23人攜帶該突變，10人已確診癌癥。而最近通過聯合調查后確認，至少197名兒童通過該捐精者的精子出生，但由于部分國家缺乏數據，實際人數可能更多。

23 children with the genetic mutation had been discovered, out of 67 children linked to the donor. Ten of those children with the mutation had already been diagnosed with cancer.

mutation /mju??te??(?)n/ 變異

Freedom of Information requests submitted by journalists across multiple countries revealed at least 197 children were affected, though it is not known how many inherited the genetic mutation.

法國魯昂大學醫院卡斯帕醫生透露：“許多孩子已經罹患癌癥，有些甚至患有兩種不同癌癥，一些人已經在非常幼小的年紀死亡。”

"We have some children that have developed already two different cancers and some of them have already died at a very early age," Edwige Kasper, a cancer geneticist at France's Rouen University Hospital, told journalists.

法國單親媽媽塞琳女兒確診基因突變，她不怪捐精男子本人，但認為診所提供問題精子不可接受。負責銷售該精子的“丹麥歐洲精子銀行”發現問題后封存受影響精子，向受影響家庭致歉。

來源：瀟湘晨報 大河報 美國哥倫比亞廣播公司

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