疫苗前沿 | 帶狀皰疹疾病及疫苗研發進展

本期我們關注一種常見病原體水痘-帶狀皰疹病毒導致的疾病-帶狀皰疹，了解目前的疾病負擔和疫苗研發進展。

帶狀皰疹的疾病負擔有多大？

帶狀皰疹（herpes zoster, HZ）是由長期潛伏在脊髓后根神經節或顱神經節內的水痘-帶狀皰疹病毒（varicella-zoster virus，VZV）經再激活引起的感染性皮膚病。

帶狀皰疹是皮膚科常見病，除皮膚損害外，常伴有神經病理性疼痛，多見于年齡較大、免疫抑制或免疫功能缺陷等人群，該疾病嚴重影響患者生活質量。

2025年7月，WHO發布的帶狀皰疹疫苗立場文件顯示：2020年全球≥50歲人群中新發1490萬例帶狀皰疹（herpes zoster, HZ)，預計到2030年，這一數字將升至1910萬。同時，HZ的終生患病率為30%，其帶來的帶狀皰疹后神經痛（PHN）嚴重影響患者生活質量，全球人口老齡化的進展更是推動其疾病負擔不斷上升。

參考資料

·Mortimer KJ, Cruz AA, Sepúlveda-Pachón IT, Jorga A, Vroling H, Williams C. Global herpes zoster burden in adults with asthma: a systematic review and meta-analysis. Eur Respir J. 2024;64(2):2400462. Published 2024 Aug 8. doi:10.1183/13993003.00462-2024

·van Oorschot D, Vroling H, Bunge E, Diaz-Decaro J, Curran D, Yawn B. A systematic literature review of herpes zoster incidence worldwide. Hum Vaccin Immunother. 2021;17(6):1714-1732. doi:10.1080/21645515.2020.1847582

·Zheng B, Yin D, Geng Y, et al. Herpes zoster incidence and burden in older Chinese: a systematic review and meta-analysis. BMC Public Health. 2025;25(1):1494. Published 2025 Apr 22. doi:10.1186/s12889-025-22703-6

·World Health Organization. WHO position paper on herpes zoster vaccines – July 2025. Wkly Epidemiol Rec. 2025;100(27-28):265-284. Published July 4, 2025. Accessed November 9, 2025. Available at:

https://www.nitag-resource.org/sites/default/files/2025-07/WER10027-28-265-284.pdf

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https://www.rhegen.com/show-8-33-1.html

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https://www.sinopharm.com/2025-04/14/c_20034.htm

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編輯 設計| Alice